|
KMID : 1143420200130140851
|
|
Public Health Weekly Report
2020 Volume.13 No. 14 p.851 ~ p.861
|
|
|
Surveillance of Acute Flaccid Paralysis in the Republic of Korea, 2018
|
|
Lee Yong-Pyo
Kang Hae-Ji
Choi Woo-Young
Han Myung-Guk
|
|
|
Abstract
|
|
|
Background: Acute flaccid paralysis (AFP) is described as sudden onset of flaccid paralysis in one or more limbs in children may be caused by poliovirus. As Polio national-laboratory was undertaken by World Health Organization (WHO) in 1991, the Korea Center for Diseases Control and Prevention has conducted its surveillance system to monitor the progress of poliomyelitis eradication since 1998. One of WHO’s indicators for polio elimination is strengthening of surveillance by
maintaining the number of reported non-polio AFP cases per 100,000 children aged less than 15 years equivalent.
Methods: The AFP surveillance was conducted through repor ting and laborator y testing according to WHO recommendations. Conventional tube cell culture method was used for virus isolation and the isolates were identified by ITD (Intratypic differentiation) kit. For viral detection, clinical specimens were tested, using both real-time reverse transcription polymerase reaction (Real-time RT-PCR) and nested RT-PCR to amplify part of 5’NCR and VP1 gene respectively.
Results: Non-polio AFP rate was 1.04 in 2018. 70 cases were reported from nine provinces in 2018. A total of 142 clinical
specimens were collected from 70 patients, 6 cases were positive for non-polio enterovirus (NPEV) which were identified as Echovirus 3, Echovirus 13, Echovirus 30, Enterovirus 71 and Coxsackievirus B5. In 2018, among the total of 70 cases, Guillain- Barre Syndrome (38.6%, 27/70) was the major leading cause of AFP.
Conclusion: This surveillance represented a national-based survey of AFP and could provide evidence that Korea continues to maintain polio-free status.
|
|
|
KEYWORD
|
|
|
Acute Flaccid Paralysis, Poliovirus, Enterovirus, Poliomyelitis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|